分析仪器

本实验建立了医院废水中苯丙胺类药物残留的气相色谱-串联质谱测定方法，该方法可同时测定苯丙胺等12种目标化合物的含量。结果表明，在采用乙酸乙酯作为提取溶剂、3 g氯化钠作为盐析剂的液液萃取法前处理条件下，该方法对目标化合物的萃取效果最佳。方法学验证结果表明，苯丙胺等12种目标化合物在5～1000 ng·L^-1范围内线性关系良好，相关系数均不低于0.9950，检出限为0.04～0.25 ng·L^-1，定量限为0.12～0.80 ng·L^-1，加标回收率范围为82.1%～99.2%，相对标准偏差(RSD)范围为2.3%～8.5%。综上，该方法具有较高的灵敏度、正确度和精密度，操作简便、可靠性高，适用于医院废水中苯丙胺类药物残留的监测，可为环境水体中该类物质残留的评估与管控提供技术参考。

This method could simultaneously determine the content of 12 target compounds such as amphetamine. The results showed that the method had the best extraction effect on the target compounds under the pretreatment conditions of liquid-liquid extraction with ethyl acetate as the extraction solvent and 3g of sodium chloride as the salting-out agent. The results of methodological verification showed that the linear relationship of 12 target compounds such as amphetamine was good in the range of 5-1000 ng·L^-1, the correlation coefficient was not less than 0.9950, the detection limit was 0.04-0.25 ng·L^-1, the limit of quantitation was 0.12-0.80 ng·L^-1, the recovery rate was 82.1%-99.2%, and the relative standard deviation( RSD) was 2.3%-8.5%. In summary, this method has high sensitivity, accuracy and precision, simple operation and high reliability. It is suitable for the monitoring of amphetamines residues in hospital wastewater, and can provide technical reference for the evaluation and control of such substances residues in environmental water.