陈泽雄,周志洪,巫陪山,马艳芳

• 1:广州市环境监测中心站
• 2:广东省科学院中国广州分析测试中心广东省化学危害应急检测技术重点实验室

摘要(Abstract)：

建立了超高效液相色谱-三重四级杆串联质谱(UHPLC-MS/MS)同时测定地表水和污水中3种典型"三高"药物硝苯地平、格列吡嗪和吉非罗齐的分析方法。水样采用Oasis HLB小柱,通过固相萃取方式进行富集、净化,经甲醇/二氯甲烷/乙酸乙酯洗脱后,UPLC-MS/MS进行检测。硝苯地平、格列吡嗪和吉非罗齐在标准曲线溶液中的线性相关系数r2分别为0.9989、0.9996和0.9998。对于地表水样品,3种目标药物的回收率范围分别为95%～103%、111%～126%和91%～98%,检测限(MQLs,S/N>10)范围为0.13ng/L～0.79ng/L,基质效应范围为-3.2%～13%;对于污水样品,3种目标药物的回收率范围分别为71%～80%、87%～113%和105%～112%,MQLs范围为3.35ng/L～6.32ng/L,基质效应范围为-14%～19%。方法应用于环境污水样品,检测出硝苯地平浓度为8.7ng/L。本方法灵敏可靠,可用于环境水体中典型"三高"药物的多残留筛查与痕量检测。

关键词(KeyWords)： 硝苯地平;格列吡嗪;吉非罗齐;多残留筛查;痕量分析

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陈泽雄,周志洪,巫陪山,马艳芳

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